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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Intra-amniotic transplantation of brain-derived neurotrophic factor-modified mesenchymal stem cells treatment for rat fetuses with spina bifida aperta

Fig. 1

Expression pattern of BDNF in the spinal cords of normal and SBA rat fetuses. A. A typical back photograph from a normal fetus and an SBA fetus induced by atRA. B. Expression-level analysis of BDNF mRNA in normal and SBA spinal cords on E12, E15, E18, and E21. C–F. Immunodetection of BDNF protein in the spinal cords of normal and SBA fetuses at E12, E15, E18, and E21 by simple western shows a significant reduction in BDNF protein in the SBA spinal cords. Gray–white stripes were detected by the HRP channel; red stripes were detected by the NIR channel. The stripes and quantification of relative protein levels were determined from peak areas detected by a size-based capillary electrophoresis instrument. Abbreviations: N: normal fetal rat spinal cord, SBA: spina bifida aperta, E: embryonic days, *p < 0.05

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