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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Diabetic microenvironment preconditioning of adipose tissue-derived mesenchymal stem cells enhances their anti-diabetic, anti-long-term complications, and anti-inflammatory effects in type 2 diabetic rats

Fig. 3

Identification of T2D model and multiple pre-ADSCs infusions improved glucose homeostasis, insulin resistance and islet damage of long-term T2D complication rats. Blood glucose levels were detected consecutively after ADSCs or pre-ADSCs infusions (A). Concentration of glucose in the blood of four groups after a IPGTT (B) or IPITT (C). HOMA-IR of each group (D). GIR of hyperinsulinaemic-euglycaemic clamp analysis of each group (E). The above findings are all expressed as mean ± standard deviation. The presence and distribution of insulin- (green) and glucagon-producing (red) cells were measured (I). Bars = 100 μm (F). The β cell mass and percentage of β cells in the pancreatic islets were evaluated (G, H). *P < 0.05, **P < 0.01

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Stem Cell Research & Therapy

ISSN: 1757-6512