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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Diabetic microenvironment preconditioning of adipose tissue-derived mesenchymal stem cells enhances their anti-diabetic, anti-long-term complications, and anti-inflammatory effects in type 2 diabetic rats

Fig. 6

Multiple pre-ADSCs infusions ameliorated long-term T2D induced diseases of lung and eye. Representative lung sections by H&E, PAS, and Masson’s trichrome staining; bars = 20, 10 and 50 μm (A). Lung injury scores were evaluated via H&E-stained sections (B). Ratio of PAS staining-positive area to whole area (C). Ratio of Masson staining-positive area to whole area (D). Immunohistochemical staining and quantification of α-SMA area; bars = 100 μm (E, F). Quantitative reverse transcriptase polymerase chain reaction analysis of gene expression in lung tissue from control, T2D, ADSCs and pre-ADSCs groups; results are presented relative to those of control rats, set as 1. N = 6 rats per group (G, H); Representative photographs using the camera and representative sections staining with H&E; bars = 50 μm (I, J), results are presented relative to those of control rats, set as 1. N = 6 rats per group. *P < 0.05, **P < 0.01

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