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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Characterizing the secretome of licensed hiPSC-derived MSCs

Fig. 2

Licensing secretome of hiMSCs and hBMSCs. (A) Concentration of well-known immunomodulatory cytokines (pg/mL) in conditioned media upon licensing of hiMSCs or hBMSCs with TNFα and IFNγ. (B) Jaccard similarity plots for transcriptome wide Pearson correlations between unlicensed and licensed hMSCs as specified (individual correlations indicated in each pie chart; average correlation across cells indicated left to the plots). (C) Fold-changes in expression levels of well-known immunomodulatory genes upon licensing of hiMSCs or hBMSCs. (D) Fold-changes in expression levels of FDR significant genes with highest fold up- or downregulation upon licensing of hiMSCs or hBMSCs (significant differences indicated with *P < 0.05; **P < 0.01; ***P < 0.001)

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