Table 1 The licensed hiMSC-secretome and enriched biological pathways
From: Characterizing the secretome of licensed hiPSC-derived MSCs
A | |||
|---|---|---|---|
hiMSCs | |||
Upreglated Genes | P value | FDR | FC |
CXCL8/IL8 | 0.00 | 0.00 | 60,398 |
ICAM1 | 0.00 | 0.00 | 30,931 |
IFI44L | 0.00 | 0.00 | 10,724 |
SAMD9L | 0.00 | 0.00 | 7551 |
MX1 | 0.00 | 0.00 | 6487 |
GBP1 | 0.00 | 0.00 | 4186 |
IL6 | 0.00 | 0.00 | 3208 |
HLA-DRA | 0.00 | 0.00 | 2552 |
GCH1 | 0.00 | 0.00 | 2528 |
HLA-B | 0.00 | 0.00 | 2257 |
APOL6 | 0.00 | 0.00 | 1689 |
CTSS | 0.00 | 0.00 | 1011 |
TNFAIP3 | 0.00 | 0.00 | 969 |
SERPINB2 | 0.00 | 0.00 | 934 |
C15orf48 | 0.00 | 0.00 | 793 |
10− | |||
B | |||
|---|---|---|---|
hiMSCs | |||
Downregulated Genes | P value | FDR | FC |
TNFRSF10D | 0.00 | 0.00 | -109.1 |
THBS2/TSP2 | 1.3 × 10–293 | 3.4 × 10–291 | -57.8 |
IGFBP5 | 4.2 × 10–268 | 9.5 × 10–266 | -98.2 |
PRPS1 | 1.8 × 10–246 | 3.4 × 10–244 | -30.5 |
SFRP1 | 2.6 × 10–237 | 4.5 × 10–235 | -17.8 |
LRRC17 | 6.8 × 10–228 | 1.1 × 10–225 | -129.5 |
PDE1C | 1.5 × 10–226 | 2.3 × 10–224 | -31.3 |
LAMA4 | 2.2 × 10–195 | 2.9 × 10–193 | -15.6 |
DUSP4 | 1.5 × 10–183 | 1.9 × 10–181 | -21.5 |
PSD3 | 9.8 × 10–172 | 1.1 × 10–169 | -14.7 |
AK5 | 5.3 × 10–157 | 5.3 × 10–155 | -28.7 |
SESN3 | 6.8 × 10–136 | 6.0 × 10–134 | -62.8 |
GALNT5 | 1.6 × 10–133 | 1.4 × 10–131 | -20.7 |
PAMR1 | 2.2 × 10–133 | 1.9 × 10–131 | -53.2 |
CPA4 | 9.0 × 10–122 | 7.1 × 10–120 | -20.2 |
C | ||
|---|---|---|
Biological Pathways (upregulated genes) | P Value | Fold Enr |
GO:0006955 ~ immune response | 6.2 × 10–23 | 11.7 |
GO:0060333 ~ interferon-gamma-mediated signaling pathway | 2.4 × 10–20 | 41.3 |
GO:0006954 ~ inflammatory response | 1.2 × 10–17 | 11.1 |
GO:0071346 ~ cellular response to interferon-gamma | 1.5 × 10–16 | 28.2 |
GO:0030593 ~ neutrophil chemotaxis | 3.4 × 10–16 | 32.2 |
GO:0070098 ~ chemokinx10-mediated signaling pathway | 2.2 × 10–15 | 34.6 |
GO:0051607 ~ defense response to virus | 4.9 × 10–14 | 14.2 |
GO:0060337 ~ type I interferon signaling pathway | 8.0 × 10–14 | 32.4 |
GO:0006935 ~ chemotaxis | 9.6 × 10–14 | 21.2 |
GO:0019882 ~ antigen processing and presentation | 2.8 × 10–12 | 39.6 |
TFBS | P Value | Fold Enr |
|---|---|---|
NFKAPPAB | 4.4 × 10–02 | 1.3 |
D | ||
|---|---|---|
Biological Pathways (downregulated genes) | P Value | Fold Enr |
GO:0043406 ~ positive regulation of MAP kinase activity | 5.0 × 10–03 | 27.2 |
GO:0044267 ~ cellular protein metabolic process | 1.7 × 10–02 | 14.3 |
GO:0007507 ~ heart development | 3.3 × 10–02 | 10.0 |
GO:0007155 ~ cell adhesion | 3.7 × 10–02 | 5.2 |
GO:0048565 ~ digestive tract development | 3.8 × 10–02 | 49.4 |
GO:0048863 ~ stem cell differentiation | 4.3 × 10–02 | 43.4 |
TFBS | P Value | Fold Enr |
|---|---|---|
NKX25 | 1.45E-05 | 1.7 |
TAL1BETAITF2 | 9.37E-05 | 1.8 |
CEBPB | 2.05E-04 | 1.8 |
SOX5 | 3.07E-04 | 1.9 |
IRF7 | 5.19E-04 | 1.9 |
BRN2 | 6.38E-04 | 1.8 |
NKX3A | 7.05E-04 | 1.9 |
POU6F1 | 7.51E-04 | 2.0 |
NKX61 | 1.00E-03 | 1.9 |
RP58 | 1.12E-03 | 1.7 |
LHX3 | 1.55E-03 | 2.0 |
NF1 | 1.86E-03 | 2.0 |
HOXA3 | 2.11E-03 | 1.9 |
HSF2 | 2.18E-03 | 1.9 |
SRY | 2.20E-03 | 1.9 |
MEIS1BHOXA9 | 2.55E-03 | 1.7 |
CDP | 3.44E-03 | 1.6 |
HNF1 | 3.59E-03 | 1.6 |
CART1 | 3.67E-03 | 1.7 |
CREBP1 | 3.91E-03 | 1.7 |
ISRE | 4.23E-03 | 1.8 |
GATA | 5.33E-03 | 1.7 |
PBX1 | 5.86E-03 | 1.6 |
GATA6 | 6.08E-03 | 2.7 |
FOXO1 | 6.26E-03 | 1.8 |
EVI1 | 6.30E-03 | 1.3 |
EN1 | 6.32E-03 | 1.6 |
OCT | 7.79E-03 | 1.7 |
LMO2COM | 7.85E-03 | 1.5 |
POU3F2 | 9.31E-03 | 1.5 |
AP1 | 9.51E-03 | 1.5 |
TBP | 1.03E-02 | 1.9 |
FAC1 | 1.07E-02 | 1.6 |
NKX22 | 1.39E-02 | 1.7 |
FREAC7 | 1.47E-02 | 1.6 |
FOXJ2 | 1.51E-02 | 1.4 |
STAT5A | 1.61E-02 | 1.5 |
CDC5 | 1.64E-02 | 1.6 |
HTF | 1.85E-02 | 1.5 |
LUN1 | 1.85E-02 | 1.6 |
BACH1 | 2.03E-02 | 1.6 |
USF | 2.20E-02 | 1.5 |
CEBP | 2.24E-02 | 1.3 |
ER | 2.45E-02 | 1.5 |
MRF2 | 2.53E-02 | 1.5 |
ZIC1 | 2.66E-02 | 2.5 |
RORA2 | 2.75E-02 | 1.6 |
E4BP4 | 2.88E-02 | 1.6 |
PAX4 | 2.92E-02 | 1.3 |
CHOP | 3.08E-02 | 1.5 |
CEBPA | 3.20E-02 | 1.9 |
GFI1 | 3.37E-02 | 1.6 |
TCF11MAFG | 3.41E-02 | 1.5 |
HLF | 3.49E-02 | 1.6 |
MEF2 | 3.53E-02 | 1.3 |
OCT1 | 3.54E-02 | 1.2 |
AP2REP | 3.65E-02 | 1.6 |
HFH1 | 3.69E-02 | 1.6 |
MYB | 4.03E-02 | 1.5 |
CHX10 | 4.31E-02 | 1.6 |
HOX13 | 4.33E-02 | 1.5 |
NFAT | 4.44E-02 | 1.6 |