Skip to main content
Fig. 10 | Stem Cell Research & Therapy

Fig. 10

From: Rejuvenated endothelial progenitor cells through overexpression of cellular prion protein effectively salvaged the critical limb ischemia in rats with preexisting chronic kidney disease

Fig. 10

The protein expressions of cell-stress/cell-proliferation signaling and angiogenesis in ischemic quadriceps muscle by day 42 after CKD induction. A Protein expression of phosphorylated (p)-PI3K, * versus other groups with different symbols (†, ‡, §, ¶), p < 0.0001. B Protein expression of p-Akt, * versus other groups with different symbols (†, ‡, §, ¶), p < 0.0001. C Protein expression of p-m-TOR, * versus other groups with different symbols (†, ‡, §, ¶), p < 0.0001. D Protein expression of CD31, * versus other groups with different symbols (†, ‡, §, ¶), p < 0.0001. E Protein expression of phosphorylated endothelial nitric oxide synthase (p-eNOS), * versus other groups with different symbols (†, ‡, §, ¶), p < 0.0001. F Protein expression of vascular endothelial growth factor (VEGF), * versus other groups with different symbols (†, ‡, §, ¶), p < 0.0001. G Protein expression of stromal cell-derived factor (SDF)-1α, * versus other groups with different symbols (†, ‡, §, ¶), p < 0.0001. H Protein expression of CXCR4, * versus other groups with different symbols (†, ‡, §, ¶), p < 0.0001. All statistical analyses were performed by one-way ANOVA, followed by Bonferroni multiple comparison post hoc test (n = 6 for each group). Symbols [(*, †, ‡, §, ¶) indicate significance (at 0.05 level). SC = sham-operated control; CKD = chronic kidney disease; CLI = critical limb ischemia; EPCs = endothelial progenitor cells; PrPcOE-EPCs = overexpression of cellular prion protein in EPCs; and siPrnp-EPCs = knockdown of cellular prion protein in EPCs

Back to article page