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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Rejuvenated endothelial progenitor cells through overexpression of cellular prion protein effectively salvaged the critical limb ischemia in rats with preexisting chronic kidney disease

Fig. 6

Ischemic to normal blood flow (INBF) ratio measured by laser Doppler scan at days 0, 1, 7 and 14 after left CLI induction. AE Illustrating the laser Doppler finding of ratio of left hind limb (ischemia) to right hind limb (normal) blood flow (i.e., INBF) at day 0 prior to critical limb ischemia (CLI) procedure among the five groups. F Analytical result of ratio of INBF, p > 0.5. GK Illustrating the laser Doppler finding of INBF at day 1 after CLI procedure among the five groups. L Analytical result of ratio of INBF, * versus †, p < 0.0001. MQ Illustrating the laser Doppler finding of ratio of INBF at day 7 after CLI procedure among the five groups. R Analytical result of ratio of INBF, * versus other groups with different symbols (†, ‡, §, ¶), p < 0.0001. SW Illustrating the laser Doppler finding of ratio of INBF at day 14 after CLI procedure among the FIVE groups. X Analytical result of ratio of INBF, * versus other groups with different symbols (†, ‡, §, ¶), p < 0.0001. Note that each rat was placed in a supine position and the tail in upward direction. Thus, the left side of animal indicated the left critical limb and the attenuated Doppler color, i.e., implicated a reduction in blood flow in left CLI area, was clearly observed. All statistical analyses were performed by one-way ANOVA, followed by Bonferroni multiple comparison post hoc test (n = 8 for each group). Symbols (*, †, ‡, §, ¶) indicate significance (at 0.05 level). L = left limb; R = limb; right SC = sham-operated control; CKD = chronic kidney disease; CLI = critical limb ischemia; EPCs = endothelial progenitor cells; PrPcOE-EPCs = overexpression of cellular prion protein in EPCs; and siPrnp-EPCs = knockdown of cellular prion protein in EPCs

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