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Fig. 9 | Stem Cell Research & Therapy

Fig. 9

From: Rejuvenated endothelial progenitor cells through overexpression of cellular prion protein effectively salvaged the critical limb ischemia in rats with preexisting chronic kidney disease

Fig. 9

The protein expressions of apoptotic and fibrotic biomarkers and PrPc in ischemic quadriceps muscle by day 42 after CKD induction. A Protein expression of mitochondrial Bax (Mit-Bax), * versus other groups with different symbols (†, ‡, §, ¶), p < 0.0001. B Protein expression of cleaved caspase 3 (c-Casp3), * versus other groups with different symbols (†, ‡, §, ¶), p < 0.0001. C Protein expression of cleaved poly (ADP-ribose) polymerase (c-PARP), * versus other groups with different symbols (†, ‡, §, ¶), p < 0.0001. D Protein expression of phosphorylated (p)-Smad3, * versus other groups with different symbols (†, ‡, §, ¶), p < 0.0001. E Protein expression of transforming growth factor (TGF)-ß, * versus other groups with different symbols (†, ‡, §, ¶), p < 0.0001. F Protein expression of cellular prion protein (PrPc), * versus other groups with different symbols (†, ‡, §, ¶), p < 0.0001. All statistical analyses were performed by one-way ANOVA, followed by Bonferroni multiple comparison post hoc test (n = 6 for each group). Symbols [(*, †, ‡, §, ¶) indicate significance (at 0.05 level). SC = sham-operated control; CKD = chronic kidney disease; CLI = critical limb ischemia; EPCs = endothelial progenitor cells; PrPcOE-EPCs = overexpression of cellular prion protein in EPCs; and siPrnp-EPCs = knockdown of cellular prion protein in EPCs

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