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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Oct4 cooperates with c-Myc to improve mesenchymal-to-endothelial transition and myocardial repair of cardiac-resident mesenchymal stem cells

Fig. 1

The effects of myocardial ischemia on the secretion profile of cMSCs. Rat angiogenesis arrays were utilized in order to analyze supernatants after a 48 h incubation to evaluate the effect of myocardial ischemia on MSC cytokine profiles in the conditioned medium collected from the cells post-MI and compared them with their sham counterparts. cMSCs from ischemic rats significantly changed their paracrine profile, compared with their sham counterparts. Ischem cMSCs became more inflammatory with decreased anti-inflammatory and proangiogenic factors (A and B). Results are presented as the percent of spot density to control ± SEM. Independent samples t test was used (n = 5 per group). (C–F) Direct fluorescence staining with IL-1α/IL-4 (C and D) and Ang1/bFGF (E and F) in MSCs derived from ischemic rats, compared with sham-operated rats, and counterstained with DAPI. DAPI, 4’, 6-diamidino-2-phenylindole

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Stem Cell Research & Therapy

ISSN: 1757-6512