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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: iPSCs derived from insulin resistant offspring of type 2 diabetic patients show increased oxidative stress and lactate secretion

Fig. 4

IR-iPSCs manifest increased cellular oxidative stress. A Gene ontology for upregulated genes in IR-iPSCs individually compared to IS-iPSCs obtained by RNA-Seq. B ROS quantification using the DCFH-DA by flow-cytometry in basal states showed increased expression in IR-iPSCs. C Annexin V quantification by flow-cytometry in iPSCs-treated with 0.5 mM H2O2 showed increased susceptibility of IR-iPSCs to oxidative stress

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