Table 2 Comprehensive comparison of Muse cells and other stem cells
From: Muse cells: ushering in a new era of stem cell-based therapy for stroke
| Â | ESCs | iPSCs | MSCs | Muse cells |
|---|---|---|---|---|
Origin | Embryos | Somatic cells | Various tissues | Various tissues |
Richness | – |  +  |  +  | – |
Ethical problem |  +  +  +  | - | - | – |
Type | Pluripotent | Pluripotent | Multipotent | Pluripotent |
Three-germ layers differentiation |  +  +  +  |  +  +  +  |  +  |  +  +  +  |
Immunogenicity |  +  |  +  | – | – |
Autologous | – |  +  |  +  |  +  |
Immunomodulation | – | – |  +  |  +  |
Tumorigenicity |  +  |  +  | – | – |
HLA matching |  +  | – | – | – |
Technological difficulty of isolation/culture |  +  |  +  | – | – |
Grow character | Suspension/adhesion | Adhesion | Adhesion | Suspension/adhesion |
Division method | Symmetric | Symmetric | Symmetric | Symmetric /asymmetric |
Stress tolerance |  +  |  +  |  +  |  +  +  +  |
Differentiation prior to transplantation | Necessary | Necessary | Not necessary | Not necessary |