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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: ADSCs stimulated by VEGF-C alleviate intestinal inflammation via dual mechanisms of enhancing lymphatic drainage by a VEGF-C/VEGFR-3-dependent mechanism and inhibiting the NF-κB pathway by the secretome

Fig. 3

Secretome in the supernatants of ADSCs stimulated with or without VEGF-C in vitro and their effects of LECs migration, VEGF-C/VEGFR-3 expression. a Concentrations of proinflammatory cytokines (IFN-γ, IL-6) and anti-inflammatory cytokines (IL-10) in cell culture supernatants were detected by ELISA. b Concentrations of growth factors (VEGF-C, TGF-β1, IGF-1, FGF-2) in cell culture supernatants detected by ELISA. (N = 4, *P < 0.05, **P < 0.01) c Representative images of LEC migration per group were captured at 12 h. Scale bar 100 μm; × 100, magnifications. d Quantification of transwell migration assay data. e Relative mRNA expression levels of VEGF-C. f Relative mRNA expression levels of VEGFR-3. (N = 3, *P < 0.05, **P < 0.01). ELISA results are shown as the means ± standard deviation (SD) while migration count and mRNA data are presented as the means ± standard errors (SEM)

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Stem Cell Research & Therapy

ISSN: 1757-6512