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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Priming mesenchymal stem cells with α-synuclein enhances neuroprotective properties through induction of autophagy in Parkinsonian models

Fig. 3

α-Syn enhances MSC glycolysis by upregulating PKM and LDH. A Glucose uptake by MSC is not affected by α-syn-treatment. B α-Syn-treated MSCs present an increased accumulation of lactate compared with that by control MSCs. C–F α-Syn-treated MSCs exhibit increased mRNA levels of glycolysis enzymes, such as HK1, HK2, PFKFB3, PKM, and LDH, compared to the control MSCs. G–I mRNA levels of pentose-phosphate pathway enzymes, such as G6PD, PGD, and TKT, show no significant differences in α-syn-treated MSCs compared with that of control MSCs. Data are presented as mean ± SE. *P < 0.05; **P < 0.01

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Stem Cell Research & Therapy

ISSN: 1757-6512