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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Determining the optimal stage for cryopreservation of human embryonic stem cell-derived retinal pigment epithelial cells

Fig. 4

PCA and DEG analysis among the three groups of hESC-derived RPE. A PCA analysis of transcriptome for three-time points. B. Hierarchical clustering of all DEGs. C, D. Volcano plots of DEGs between P2D5 and P1D35 (P2D5 vs. P1D35) (C) and between P2D5 and P2D11 (D), respectively. Genes without significant differences are indicated by blue dots. The red dots indicate the upregulated genes, and the green dots indicate the down-regulated genes. Genes that are not significantly different between the two groups are indicated by blue dots. E. Venn diagram showing the overlap in the down-regulated DEGs between P2D5 versus P1D35 and P2D5 versus P2D11. F Venn diagram showing the overlap in the upregulated DEGs between P2D5 versus P1D35 and P2D5 versus P2D11. The numbers in each circle indicate the total number of different genes in each comparison group, and the number in the overlapping area represents the number of common genes between the two comparison groups

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Stem Cell Research & Therapy

ISSN: 1757-6512