Fig. 5
GO enrichment and KEGG pathway analysis. A Dot plots displaying the top 30 enriched GO categories among the shared down-regulated DEGs in P2D5 versus P1D35 and P2D11. B Dot plots displaying the top 30 enriched GO categories among the shared upregulated DEGs in P2D5 versus P1D35 and P2D11. The size of the circles indicates the number of DEGs that fall into the GO terms. The color of the circle represents the significance of the enriched GO terms. C KEGG pathways significantly enriched in shared upregulated DEGs in P2D5 vesus P1D35 and P2D11 (Padj < 0.05). D Heatmap representing the relative FPKM of cell cycle-associated genes indicated by KEGG pathway analysis among the samples (normalized to average FPKM of P2D5 group). E Heatmap represented the FPKM of ECM-receptor interaction associated genes indicated by KEGG pathway analysis among the samples (normalized to average FPKM of P2D5 group). F Protein–protein interaction (PPI) network diagram of the DEGs that were clustered in significantly enriched KEGG pathways. Line thickness indicates the strength of data support