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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Systemic proteomics and miRNA profile analysis of exosomes derived from human pluripotent stem cells

Fig. 3

The shared proteins had different signaling regulation abilities when performing pairwise bioinformatics analysis. A, D, and G KEGG analyses of overlapping proteins in hESC-Exos and hiPSC-Exos A, hESC-Exos and hUC-MSC-Exos B, and hiPSC-Exos and hUC-MSC-Exos G. The red bar and black dot represent the -Log10 (P-value) and the proportion of candidate genes in the total pathway-related gene pool, respectively. B, E, and H Volcano diagrams of differentially expressed proteins in hESC-Exos vs hiPSC-Exos B, hESC-Exos vs hUC-MSC-Exos E, and hiPSC-Exos vs hUC-MSC-Exos E at P < 0.05 and |log2FC|≥ 1. Histogram of the GO and KEGG analyses of upregulated protein clusters ranked from high to low significance. C, F, and I Heatmap of the levels of shared proteins between hESC-Exos and hiPSC-Exos C, hESC-Exos and hUC-MSC-Exos F, and hiPSC-Exos and hUC-MSC-Exos I. The significantly enriched pathways are shown on the right

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