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Table 3 Clinical characteristics and outcomes of patients

From: Topical and intravenous administration of human umbilical cord mesenchymal stem cells in patients with diabetic foot ulcer and peripheral arterial disease: a phase I pilot study with a 3-year follow-up

Clinical features

All (n = 14)

Age ≥ 55 (n = 7)

Age < 55 (n = 7)

Demographics

 Gender

  Male, n (%)

11 (79)

6 (86)

5 (71)

  Female, n (%)

3 (21)

1 (14)

2 (29)

 Age, y

   

  Median (IQR), y

54.0 (47.2–65.7)

65.0 (56.0–75.0)

49.0 (39.0–53.0)

Duration since diagnosis of DM, y

  Median (IQR), y

9.0 (4.7–12.2)

11.0 (5.0–13.0)

6.0 (4.0–12.0)

HbA1c at baseline

  Median (IQR), %

7.3 (6.9–7.9)

7.0 (6.5–7.8)

7.6 (7.0–8.3)

Main comorbidities

 Diabetic peripheral neuropathy, n (%)

9 (64)

5 (71)

4 (57)

 Diabetic nephropathy, n (%)

7 (50)

4 (57)

3 (43)

 Diabetic retinopathy, n (%)

3 (21)

2 (29)

1 (14)

 Hypertension, n (%)

6 (43)

4 (57)

2 (29)

 Cerebrovascular disease, n (%)

4 (29)

3 (43)

1 (14)

Amputation history, n (%)

1 (7)

1 (14)

0

Outcomes

 Ulcer status at 1.5-month FU a

  Complete closure, n (%)

14 (93)

7 (88)

7 (100)

  Incomplete closure b, n (%)

1 (7)

1 (12)

0

 Rehospitalization for DFU

  Proportion, n (%)

5 (36)

3 (43)

2 (29)

  Mean ± SD, y

2.0 ± 0.6

1.8 ± 0.7

2.3 ± 0.2

 Amputation, n (%)

1 (7)

1 (14)

0

  First amputation interval, y

3.6

3.6

NA

  Amputation plane

Midfoot

Midfoot

NA

Survival at 3-year FU, n (%)

14 (100)

7 (100)

7 (100)

  1. aThere were 15 ulcers for assessments since one patient had two ulcers for treatments
  2. bThe closure area could not achieved 100% of the lesion area
  3. DFU diabetic foot ulcer, DM diabetes mellitus, FU follow-up, IQR interquartile range, SD standard deviation