Fig. 2From: Cancer cells as a new source of induced pluripotent stem cellsThe mechanism of iPSCs generation in vitro. The induction of TCF1/TCF3 is necessary to initiate reprogramming. Then E-Ras, PI3/Akt, and STAT3/Gbx2 pathways activate, and FOXO1 and mTOR pathways are inhibited. In the late stage, Wnt activation starts via deletion of TCF3/TCF4, resulting in iPSCs generationBack to article page