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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: Human umbilical cord mesenchymal stem cells ameliorate erectile dysfunction in rats with diabetes mellitus through the attenuation of ferroptosis

Fig. 8

HUCMSCs attenuated ferroptosis through the SLC7A11/GPX4/ACSL4 pathway in vitro. Representative immunoblot (A) and quantification (B–F) of SLC7A11, GPX4, ACSL4, LPCAT3 and ALOX15 in CCSMCs of each group. Representative immunofluorescence (× 200) (G) and quantification (I) of ACSL4 in CCSMCs of each group. Representative immunofluorescence (× 200) (H) and quantification (J) of GPX4 in CCSMCs of each group. Data are expressed as means ± standard deviation. *P < 0.05 versus the control group; #P < 0.05 versus the HG group. Con control, HG high glucose, Fer-1 ferrostatin-1, IOD integrated option density, DAPI 4’,6-diamidino-2-phenylindole

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