Table 1 Human umbilical cord blood mononuclear cells transplantation for perinatal brain injury

CD34 + cells

7 days after HI

1.5*10⁴

Tail vein

Ameliorated the neural functional defect and reduced apoptosis and promoted nerve and vascular regeneration

inhibited the expression of apoptosis-related genes, such as TNF-α, TNFR1, TNFR2, CD40, Fas

44

UCB-MNCs

6 h after HI

1*10⁷

Intraperitoneal

Didn’t induce long-term morphological or functional protection

inhibited apoptosis and oxidative stress

⁴⁵

UCB-MNCs

7 days after HI

1.5*10³

Jugular vein

Less impaired in motor asymmetry and motor coordination

Up-regulation of neurotropic factor, such as GDNF, NGF and BDNF

⁴⁶

UCB-MNCs

24 h after HI

1*10⁷

Intraperitoneal

Improved spastic paresis

Promoting homing of MNCs to the lesion site

⁴⁷

UCB-MNCs

24 h after HI

1*10⁷

Intraperitoneal

Ameliorated brain damage

SDF-1 /CXCL12 mediated the homing of MNCs to the lesion site

⁴⁸

UCB-MNCs

24 h after HI

3*10⁶

Paracele

Promoted NSC proliferation and alleviated brain injury

Actived hedgehog signaling mediated cell proliferation pathway

⁴⁹

UCB-MNCs

7 days after HI

3*10⁷/kg

Intraperitoneal

Promoted angiogenesis in the brain injury area and reduced the area of cerebral infarction

Actived the IL-8-mediated angiogenic pathway

⁵⁰

UCB-MNCs

6 h after HI

1*10⁷

Paracele

Improved neonatal rat memory

Reduced astrogliosis, prevented neuronal loss in the striatum

¹⁶

UCB-MNCs

12 h after perinatal asphyxia

1*10⁸

Brachial artery catheter

Reduced clinical markers of brain damage following perinatal asphyxia

Reduce neuroinflammation and neuronal apoptosis

UCB-MNCs

3 h after HI

2*10⁶

Intraperitoneal

Ameliorated brain damage

Reduced activated caspase-3-mediated cell death in the striatum, and microglial activation in the cerebral cortex

⁵²

UCB-MNCs

24 h after HI

1*10⁷

Intra-arterial

prevented long-term cognitive deficits

unknown

⁵³