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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Translational development of ABCB5+ dermal mesenchymal stem cells for therapeutic induction of angiogenesis in non-healing diabetic foot ulcers

Fig. 1

HIF-1α and VEGF expression by ABCB5+ MSCs during hypoxic culture. A Representative immunofluorescence staining of ABCB5+ MSCs revealing nuclear translocation of HIF-1α at 24 h. Nuclei were counterstained with DAPI. Scale bars: 20 µm. B HIF-1α mRNA expression by ABCB5+ MSCs from two donors, shown as fold expression from baseline (normoxic conditions, 0 h). Data are means + SD of three replicates. C VEGF mRNA expression by ABCB5+ MSCs, shown as fold expression from baseline (normoxic conditions, 0 h). Data are means + SD of three donors. D VEGF protein secretion by ABCB5+ MSCS, measured as VEGF protein concentration in culture supernatant. Data are means + SD of three replicates from a representative donor

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