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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Translational development of ABCB5+ dermal mesenchymal stem cells for therapeutic induction of angiogenesis in non-healing diabetic foot ulcers

Fig. 2

Endothelial trans-differentiation of ABCB5+ MSCs. A Co-stimulation for 96 h with 200 ng/ml VEGF, 1000 ng/ml FGF-2 and 1000 ng/ml PDGF-BB elicited angiogenic trans-differentiation of ABCB5+ MSCs as revealed by CD31-positive (red) staining. B ABCB5+ MSCs cultured without growth factor supplementation served as negative control. C HUVECs served as positive control. D–F Proliferative activity of ABCB5+ MSCs stimulated to undergo endothelial trans-differentiation. D ABCB5+ MSCs were stimulated for 96 h with 200 ng/ml VEGF, 1000 ng/ml FGF-2 and 1000 ng/ml PDGF-BB. Proliferative activity was assessed by Ki67 staining (red). E ABCB5+ MSCs cultured without growth factor supplementation served as negative control. F HUVECs served as positive control. Nuclei were counterstained with DAPI (blue). Representative images of three independent experiments

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