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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Integrative network analysis of circular RNAs reveals regulatory mechanisms for hepatic specification of human iPSC-derived endoderm

Fig. 2

Expression profiles of circRNAs between DE and HE. A Normalized intensities of the differentiated cells in the DE and HE groups. B Scatter plots for assessing the circRNAs expression variation between DE and HE. (X and Y represent the averaged normalized signal values of the DE and HE groups, respectively. The middle green line refers to no different circRNAs between the groups. The flanking green lines represent 1.5-fold changes. The points above/below the flanking green lines indicate the circRNAs with 1.5-fold changes between the two groups. C Volcano plots for visualizing the identified circRNAs between the DE and HE cells. The red points represent the DEcircRNAs with statistical significance (fold change > 1.5 or < − 1.5, p < 0.05). D Hierarchical clustering of DEcircRNAs showing several circRNAs clusters between DE and HE. The red/green matrix represents the upregulated/downregulated circRNAs. E The distribution of DEcircRNAs on human chromosomes 1–22, X, Y, and M. F Annotations of the DEcircRNAs (Category: exon, intron, sense overlapping, antisense, and intergenic)

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