Fig. 2

Increased Hp levels in mice and human after PBI. A The liver of C57BL/6J mice was covered in PBI-1 and PBI-3 and in the corresponding groups PBI-2 and PBI-4 the liver was exposed. B Survival rate, Body weight, and Lymphocyte count. The P value of survival rate determined by log-rank (Mantel-Cox) test. Data are mean ± SD of n = 8 mice per group, statistical significance by Student’s t-test. Hp, haptoglobin; PBI, partial body irradiation. *, P < 0.05, and **, P < 0.01 in the TBI irradiated mice compared with the control mice. C Hp was measured using ELISA in TBI and PBI group at 0.125, 0.25, 0.5, 1, 2, 3, 5, 7, 11 and 14 days after 10 Gy radiation. Data are mean ± SD of n = 8 mice per group, statistical significance by Student’s t-test. **, P < 0.01, *, P < 0.05 in the radiated mice compared with the control mice. D Changes in serum Hp in patients with nasopharyngeal carcinoma after radiotherapy. The scatter plot shows the expression of Hp concentrations in 18 patients with nasopharyngeal carcinoma before and after radiotherapy (**, P < 0.01). The ROC curve shows that Hp was used as a biomarker to predict radiation exposure in patients with nasopharyngeal carcinoma