Parameter | CAR T-cells | CAR-NK cells |
---|---|---|
Sources | Mainly autologous T-cells | Variety of sources, including PB, UCB, HPCs, hESC, iPSCs, and cell lines |
Safety | May causes GVHD and cytokine storm | Safer, reduce the risk of cytokine storm and GVHD |
Cytotoxic mechanism | CAR-restricted cytotoxicity | Multiple mechanisms for cytotoxic activity, CAR killing capacity as well intrinsic killing capacity via natural cytotoxicity receptors |
HLA restriction | No HLA restriction | No HLA restriction |
Transduction | Higher transduction efficacy | Low transduction efficacy |
Persistence | Better persistence | Low persistence, need to exogenous cytokines |
Stability | Less susceptible to freezing and thawing | More susceptible to freezing and thawing |
Life span | Longer | Shorter |
Cost of production | Expensive | Cheaper |
Construction to injection period | Longer period of time (4–6 weeks) | Short period time, off-the-shelf |