Fig. 8

EVs enhanced angiogenesis at the mouse wound sites. a Gross view of the undersurface of wounds treated with H-EVs, P-EVs, and PBS at day 14 postwounding. Newly formed blood vessels were detected in the wound sites (scale bar, 1 mm). b CD31 immunofluorescence staining for wound sections treated with H-EVs, P-EVs, and PBS at day 14 postwounding (scale bar, 50 μm). c Quantitative analysis of the CD31-positive area in b (n = 8). d Representative images of VEGF staining for wound sections treated with H-EVs, P-EVs, and PBS at day 14 postwounding (scale bar, 50 μm). e Quantitative analysis of the VEGF-positive area in d (n = 8). **P < 0.01 versus the control group; ^##P < 0.01 versus the H-EV group