Fig. 1From: Combination of indirect revascularization and endothelial progenitor cell transplantation improved cerebral perfusion and ameliorated tauopathy in a rat model of bilateral ICA ligationSchematic representation of the experimental procedure. BICAL surgery was performed by permanent ligation of the ICA distal to the bifurcation of the CCA. One week following BICAL surgery, the craniotomy window for EMS (white dotted box) was created after downward reflection of the temporalis muscle (marked as T). Treatment with EPCs, SDF-1 or AMD3100 was administered during the EMS procedure. The rotarod test was performed 3Â days before and 3Â weeks after BICAL. Vascular density and microcirculation were evaluated 3Â weeks after BICAL. Animals were killed 3Â weeks following BICAL surgery, and brain tissues were harvested for Western blot analysis and histopathological analysisBack to article page