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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Combination of indirect revascularization and endothelial progenitor cell transplantation improved cerebral perfusion and ameliorated tauopathy in a rat model of bilateral ICA ligation

Fig. 6

EMS combined with EPC treatment protects the rat brain against BICAL-induced Tau phosphorylation. Representative immunoblot (left) and quantification (right) of A pGSK3β (Y216) and B pTau (Ser199) in the control, BICAL, and treatment group rats. EMS combined with EPC treatment significantly decreased the pGSK3β/GSK3β and pTau/Tau ratios as compared with the BICAL group. C Representative microphotography showing immunoexpression of pTau (Thr231) (shown in brown) in the cerebral cortex, hippocampus CA1, and dentate gyrus (DG) regions of the control, BICAL, and EMS combined with EPC treatment rats. *p < 0.05, **p < 0.01, ***p < 0.001, n = 4–6. Scale bars = 100 µm (upper panel) and 50 µm (lower panel)

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