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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: The effect of lncRNA MIR155HG-modified MSCs and exosome delivery to synergistically attenuate vein graft intimal hyperplasia

Fig. 7

Functional effects of OE-exo on HUVECs. A HUVECs were immune-stained with CD31 (red) and DAPI (purple). B CCK-8 assay showed that OE-exo promoted the viability of HUVECs, and sh-exo reduced cell viability (*p < 0.05). C, D OE-exo promoted migration of HUVECs, and sh-exo inhibited cell migration as demonstrated using wound healing assay (*p < 0.05). E, F Flow cytometry revealed that OE-exo reduced apoptosis of HUVECs induced by oxidative stress, and sh-exo aggravated apoptosis of HUVECs (*p < 0.05). G, H Representative western blots of Bax, GNA12, Bcl-2, and PDCD4 protein expression in HUVECs. I–L OE-exo up-regulated the expression of GNA12 and Bcl-2 in HUVECs. OE-exo reduced the expression of Bax and PDCD4 in HUVECs (*p < 0.05)

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Stem Cell Research & Therapy

ISSN: 1757-6512