Table 1 Patient history and treatment details (12-year-old, Male, Poodle); series of events in chronological order
Type of intervention | Details | Remarks |
|---|---|---|
Pre-GDEPT | ||
Surgery (lumpectomy) | (1) Lumpectomy of perineal mass; Also (2) had mass on jaw removed | Tumour samples were sent for histopathological analysis and confirmed to be (1) perianal adenoma and (2) acanthomatous ameloblastoma. Perianal mass was completely excised |
Surgery (mandibulectomy) | Partial mandibulectomy was done | Routine consultation revealed oral acanthomatous ameloblastoma has grown; scheduled surgical consult with specialist for mandibulectomy |
Surgery | Perineal mass recurred; had castration done as well | Castration was done to prevent recurrence |
| Â | Route of administration | Dosage of MSC_CD::UPRT::GFP (volume injected) | Oral 5-FC taken daily for 4Â days (mg) | Patient weight (kg) | Quality of life observation |
|---|---|---|---|---|---|
GDEPT treatment | |||||
GDEPT (cycle 1) | Intra-tumoral | 1 × 107 cells (500 µL) | 500 | 8.95 | Tumour remained stable. No vomiting and diarrhea. Patient remained active and had good appetite |
GDEPT (cycle 2) | Intra-tumoral | 1 × 107 cells (500 µL) | 500 | 9.2 | Significant weight gain and increased fur growth. Less irritable. Significant decrease in tumour volume |
GDEPT (cycle 3) | Intra-tumoral | 1 × 107 cells (500 µL) | 500 | 9.15 | Tumour volume remained stable. Improved coat condition and fur growth. Patient remained active |
Tumour progression observed 4Â months post cycle 3 | |||||
Surgical resection followed by GDEPT | Intra-cavity | 3 × 107 cells (1000 µL) | 500 | – | 22 months cancer free |