Skip to main content

Table 2 Patient history and treatment details (11-year-old, Male, Toy Poodle); series of events in chronological order

From: Cryopreservation does not change the performance and characteristics of allogenic mesenchymal stem cells highly over-expressing a cytoplasmic therapeutic transgene for cancer treatment

Type of intervention

Details

Remarks

Pre-GDEPT

Surgery

Prescapular mass removed

Patient presented to vet with incessant coughing. CT scan of the lungs revealed a 1.5 cm diameter nodule present in the left caudal lobe of the lungs

 

Route of administration

Dosage of MSC_CD::UPRT::GFP (Volume injected)

Oral 5-FC taken daily for 4 days (mg)

Patient weight (kg)

Quality of life observation

GDEPT treatment

GDEPT (Cycle 1)

Intravenous

1.5 × 107 cells (7.5 mL)@Infused at 3 mL/hr

500

3.75

Patient experienced less coughing post-treatment

Break in treatment due to COVID-19 lockdown

 GDEPT (Cycle 2)

Intravenous

1.5 × 107 cells (7.5 mL) @Infused at 3 mL/hr

500

3.65

Patient responded well to treatment. No adverse reaction was observed

 GDEPT (Cycle 3)

Intravenous

1.5 × 107 cells (7.5 mL) @Infused at 3 mL/hr

500

3.45

Patient continues to respond well

 GDEPT (Cycle 4)

Intravenous

1.5 × 107 cells (7.5 mL) @Infused at 3 mL/hr

500

3.70

Less coughing observed

 GDEPT (Cycle 5)

Intravenous

1.5 × 107 cells (7.5 mL) @Infused at 3 mL/hr

500

3.85

Post-treatment CT scan revealed stable disease. Lung nodule did not grow in size

Follow up actions

CT scan

Three month follow up

Disease continues to be stable. No progression of nodule size, nor extraordinary symptoms. Patient continues to experience good quality of life

CT scan

One year follow up

Lung nodule of interest slightly increased in size. Incidental small nodule and lymph node enlargement was also reported. Suspected metastasis. All other symptoms remain unremarkable