Fig. 3
From: Regulatory of miRNAs in tri-lineage differentiation of C3H10T1/2
The biogenesis and function of Wnt signaling pathway. a Canonical Wnt signaling pathway. In the absence of Wnt signaling, β-catenin cannot accumulate in the cytoplasm as it is degraded by a multimeric protein complex consisting of APC, Axia, CK1 and GSK3). Receptor occupancy inhibits the kinase activity of the “destruction complex”, involving the actions of the Axia-binding molecule Dvl. Consequently, due to stabilization of β-catenin by disrupted Axia-mediated phosphorylation, β-catenin accumulates and travels to the nucleus where it engages the ICF/LE complex to mediate transactivation of target genes. b The non-canonical Wnt signaling pathway is initiated by Wnt binding to Fzd, then Dvl is recruited, followed by Rac1, JNK and NFAT activation and cytoskeletal rearrangement, and then NFAT is translocated to the nucleus to activate the expression of Wnt target genes