From: Regulatory of miRNAs in tri-lineage differentiation of C3H10T1/2
miRNA | Expression | Target | Expression of target | Distribution | Function | Experiment | Animal model | References |
---|---|---|---|---|---|---|---|---|
miR-194 | ↓ | COUP-TFII | ↑ | Cytoplasm | Enforced expression of miR-194 inhibits adipocyte differentiation by decreasing COUP-TFII mRNA and protein levels | In vitro | – | [52] |
miR-140 | ↑ | Ostm1 | ↓ | Cytoplasm | miR-140 overexpression promotes BMP-4-induced adipocyte lineage commitment via decreasing the expression of Ostm1 | In vitro | – | [63] |
miR-223 | ↑ | Fgfr2 | ↓ | Cytoplasm | miR‐223 promotes adipocyte differentiation through down-regulating Fgfr2 | In vitro | – | [7] |
miR-30e | ↑ | LRP6 | ↓ | Cytoplasm | miR-30e overexpression positively affects adipocyte formation by targeting LRP6 and the canonical Wnt/β-catenin signaling | In vitro | – | [8] |
miR-27 | ↓ | Lox | ↑ | Cytoplasm | miR-27 represses adipogenic lineage commitment by inhibiting the expression of Lox | In vitro and in vivo | Mice/20 | [64] |
miR-1 | ↑ | RBM4 | ↑ | Nucleus | Overexpressing miR-1 enhances brown adipocytes differentiation via up-regulating RBM4 that enhances skipping of the MEF2Cγ region which functions as a transcriptional repressor | In vitro | – | [65] |
miR-10a-5p | ↑ | Rora, Dll4 and Nr4a3 | ↓ | Cytoplasm | miR-10a-5p performs as a positive regulator that reduces adipose tissue inflammation and promotes therapeutic adipogenesis by down-regulating anti-adipogenic molecules | In vitro and in vivo | Mice/68 | [66] |
miR-195a | ↓ | Zfp423 | ↑ | Cytoplasm | miR-195a is an anti-adipogenic regulator, which acts by negatively targeting Zfp423 | In vitro | – | [67] |
miR-20a | ↑ | KDM6B and TGFBR2 | ↓ | Cytoplasm | miR-20a promotes adipocyte progenitor cells to differentiate and this function may depend upon its inhibitory effects on KDM6B and TGF-β signaling | In vitro | – | [68] |
miR-503-5p | ↓ | Zfp217 | ↑ | Cytoplasm | there was a positive relationship between adipocyte differentiation and Zfp217 expression, which can be suppressed by miR-503-5p, miR-135a-5p and miR-19a-3p | In vitro and in vivo | Mice/12 | [69] |
miR-582-5p | ↑ | Runx2 | ↓ | Cytoplasm | miR‐582‐5p induces adipogenic differentiation by down-regulating the activity of ALP and mRNA/protein levels of ALP and Runx2 | In vitro | – | [49] |
HSA-Let-7 g | ↓ | FST and TNFRSF4 | ↑ | let-7 g down-regulation may enhance intramuscular adipogenesis during fetal muscle development possibly via down-regulating the mRNA levels of FST and TNFRSF4 | In vitro and in vivo | Mice/12 | [70] | |
miR-485 | ↑ | SRPK1 | ↓ | Cytoplasm | brown adipogenesis-induced up-regulation of miR-485 interferes with SRPK1 expression | In vitro | – | [62] |