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Table 2 Regulation of miRNAs in adipogenic differentiation of C3H10T1/2

From: Regulatory of miRNAs in tri-lineage differentiation of C3H10T1/2

miRNA

Expression

Target

Expression of target

Distribution

Function

Experiment

Animal model

References

miR-194

COUP-TFII

Cytoplasm

Enforced expression of miR-194 inhibits adipocyte differentiation by decreasing COUP-TFII mRNA and protein levels

In vitro

[52]

miR-140

Ostm1

Cytoplasm

miR-140 overexpression promotes BMP-4-induced adipocyte lineage commitment via decreasing the expression of Ostm1

In vitro

[63]

miR-223

Fgfr2

Cytoplasm

miR‐223 promotes adipocyte differentiation through down-regulating Fgfr2

In vitro

[7]

miR-30e

LRP6

Cytoplasm

miR-30e overexpression positively affects adipocyte formation by targeting LRP6 and the canonical Wnt/β-catenin signaling

In vitro

[8]

miR-27

Lox

Cytoplasm

miR-27 represses adipogenic lineage commitment by inhibiting the expression of Lox

In vitro and in vivo

Mice/20

[64]

miR-1

RBM4

Nucleus

Overexpressing miR-1 enhances brown adipocytes differentiation via up-regulating RBM4 that enhances skipping of the MEF2Cγ region which functions as a transcriptional repressor

In vitro

[65]

miR-10a-5p

Rora, Dll4 and Nr4a3

Cytoplasm

miR-10a-5p performs as a positive regulator that reduces adipose tissue inflammation and promotes therapeutic adipogenesis by down-regulating anti-adipogenic molecules

In vitro and in vivo

Mice/68

[66]

miR-195a

Zfp423

Cytoplasm

miR-195a is an anti-adipogenic regulator, which acts by negatively targeting Zfp423

In vitro

[67]

miR-20a

KDM6B and TGFBR2

Cytoplasm

miR-20a promotes adipocyte progenitor cells to differentiate and this function may depend upon its inhibitory effects on KDM6B and TGF-β signaling

In vitro

[68]

miR-503-5p

Zfp217

Cytoplasm

there was a positive relationship between adipocyte differentiation and Zfp217 expression, which can be suppressed by miR-503-5p, miR-135a-5p and miR-19a-3p

In vitro and in vivo

Mice/12

[69]

miR-582-5p

Runx2

Cytoplasm

miR‐582‐5p induces adipogenic differentiation by down-regulating the activity of ALP and mRNA/protein levels of ALP and Runx2

In vitro

[49]

HSA-Let-7 g

FST and TNFRSF4

 

let-7 g down-regulation may enhance intramuscular adipogenesis during fetal muscle development possibly via down-regulating the mRNA levels of FST and TNFRSF4

In vitro and in vivo

Mice/12

[70]

miR-485

SRPK1

Cytoplasm

brown adipogenesis-induced up-regulation of miR-485 interferes with SRPK1 expression

In vitro

[62]