Regulatory of miRNAs in tri-lineage differentiation of C3H10T1/2

Table 3 Regulation of miRNA in chondrogenic differentiation of C3H10T1/2

miRNA	Expression	Target	Expression of target	Distribution	Function	Experiment	Animal model	References
miR-135a-1-3p	↓	Hoxd10	↑	Cytoplasm	miR-135a-1-3p is a remarkably differentially expressed miRNA that targets Hoxd10, who is involved in chondrogenesis	In vitro	–	[9]
miR-124	↓	NFATc1	↑	Cytoplasm	miR-124 is down-regulated and NFATc1 is up-regulated undergoing chondrogenesis in hypoxic conditions	In vitro	–	[77]
miR-30b	↓	SOX9	↑	Cytoplasm	miR-30b is a pivotal negative modulator of TGF-β3-triggered chondrogenic differentiation, which functions via straightly inhibiting SOX9	In vitro	–	[75]
miRNA-140	↓	CXCL12	↑	Cytoplasm	miR-140 inhibition promoted MSC viability via targeting and decreasing CXCL12 protein contents during TGF-β3-triggered chondrogenic differentiation	In vitro and in vivo	Mice/18	[78]
miR-199b-5p	↑	JAG1	↓	Cytoplasm	miR-199b-5p is the positive modulators to regulate the chondrogenetic differentiative activity of via down-regulating JAG1	In vitro	–	[76]
miR-145	↓	Sox9	↑	Cytoplasm	miR-145 is a pivotal negative modulator of the chondrogenetic differentiative activity of via straightly inhibiting Sox9 at early phases of chondrogenetic differentiative activity	In vitro	–	[79]

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