Table 6 Modulation of Wnt signal pathway in tri-lineage differentiation of C3H10T1/2
From: Regulatory of miRNAs in tri-lineage differentiation of C3H10T1/2
Differentiation | Target | Expression | Expression of Wnt | Distribution | Function | Experiment | Sample | References |
|---|---|---|---|---|---|---|---|---|
Osteogenic differentiation | miR-148a | ↑ | ↓ | Cytoplasm | miR-148a suppressed osteogenic differentiation via targeting the Wnt5a/Ror2 pathway | In vivo | – | [128] |
|  | miR-483-3p | ↓ | ↑ | Cytoplasm | miR-486-3p targets CTNNBIP1, thus activating the Wnt/β-catenin signaling pathway to promote osteogenesis of C3H10T1/2 | In vivo and in vitro | Mice/42 | [129] |
|  | miR-320a | ↑ | ↓ | Nucleus | miR-320a inhibited the activity of Wnt/β-catenin signaling pathway through CTNNB1 inhibition, which cause the inhibition osteogenic differentiation in osteoporosis | In vivo and in vitro | Mice/48 | [130] |
|  | miR-19b | ↑ | ↑ | Exosome | miR-19b represses the expression of WWP1 or Smurf2 and elevates KLF5 expression through the Wnt/β-catenin signaling pathway, thereby facilitating osteogenic differentiation | In vivo | – | [131] |
Adipogenic differentiation | miR-148a | ↑ | ↓ | Cytoplasm | miR-148a promoted adipogenic differentiation via targeting the Wnt5a/Ror2 pathway | In vivo | – | [128] |
|  | miR-199a-3p | ↑ | ↓ | Cytoplasm | The overexpressed miR-199a-3p regulates adipogenesis by suppressing the activity of KDM6A/Wnt signaling | In vivo and in vitro | Mice/20 | [132] |
|  | miR-135a-5p | ↑ | ↓ | Cytoplasm | miR-135a-5p suppresses 3T3-L1 preadipocyte differentiation and adipogenesis through the activation of canonical Wnt/β-catenin signaling | In vivo | – | [133] |
Chondrogenic differentiation | miR-92a-3p | ↑ | ↑ | Nucleus | Overexpressed miR-92A-3p targets Wnt5a to enhance chondrogenic differentiation and inhibits cartilage degradation | In vivo | – | [134] |
|  | miR-8485 | ↑ | ↑ | Exosome | miR-8485 targeted GSK3B to repress GSK3β expression and targeted DACT1 to induce p-GSK3β, activating Wnt/β-catenin pathways | In vivo | – | [135] |