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Table 1 Summary of single component effects on maturation main hallmarks

From: Small molecule-mediated rapid maturation of human induced pluripotent stem cell-derived cardiomyocytes

Component

Metabolism

Cellular structure

Electrophysiology

Mitochondria

FAO

Stress test

Contractile apparatus

Polyploidism

Ion channels

Contraction

AA

↑ organization

↑ ATP synthesis

↑ lactate metabolism

↑ recovery and substrate switch

↑↑ basal respiration

↑ ATP production

↑ sarcomere

↑ > 4N

gap junction

↑ potassium

↑ sodium

calcium

↑ rise time

↑ CTD25

↑ FWHM

↑ CTD75

↑ decay time

GW

↑ organization

↑ activity

↑ ATP synthesis

↑ FAO metabolism

↑ proton leak

 

↑↑ sarcomere

 

↑↑ gap junction

↑ potassium

↑ sodium

calcium

↑ rise time

↑ CTD25

↑ FWHM

↑ decay time

T3

↑ organization

↑ activity

↑ lactate metabolism

↑ FAO metabolism

 

↑ sarcomere

 

↑↑ gap junction

↑ potassium

↑ sodium

↑ calcium

 
  1. Bold text indicates protein content