Table 2 ncRNA participation in the formation of HO
From: The role of miRNA and lncRNA in heterotopic ossification pathogenesis
Author (year) | ncRNA | Sample | Setting | HO type | ncRNA expression in HO | Effectors (Direct targets of ncRNA) | Intervention (effect on HO) |
|---|---|---|---|---|---|---|---|
Song et al. (2012) [196] | miR-148a | HeLa cells | In vitro | FOP | Decrease | ACVR1/ALK2 | NA |
Sun et al. (2016) [177] | miR-630 | Serum | Humans | Trauma | Decrease | ALP OCN OPN/SSP1 RUNX2 SLUG | miR-630 shRNA ( +) miR-630 mimics (-) |
MVECs | In vitro | ||||||
Tu et al. (2016) [68] | miR-203 | Bone | Humans Mice | Trauma | Decrease | ALP BSP RUNX2 | antagomiR-203 ( +) agomiR-203 (-) |
Ju et al. (2019) [180] | miR-421 | Serum Bone | Humans | Trauma | Decrease | BMP2 | NA |
Zhu et al. (2019) [191] | miR-19b-3p | PDGFRα + Muscle cells | In vitro | NA | Increase | ALP OCN OPN/SSP1 PTEN RUNX2 | NA |
Qin et al. (2019) [195] | miR-17-5p | Joint capsule fibroblasts | Humans In vitro | AS | Increase | ALP ANKH BMP2 COL1Al OCN RUNX2 | miR-17-5p mimics ( +) miR-17-5p inhibitor (-) |
AS rat model | Rats | ||||||
De Vasconcellos et al. (2020) [113] | miR-1 miR-133a miR-133b miR-206 | Muscle MPCs | Humans In vitro | Trauma | Increase | ALP OCN SOX9 RUNX2 | NA |
Han et al. (2021) [189] | miR-433 | Bone Serum | Humans | Trauma, NHO | Decrease | OPN/SSP1 | agomiR-433 (-) |
Jin et al. (2017) [199] | lncRNA MIAT | hASCs | In vitro | NA | Decrease | ALP OCN RUNX2 | sh-MIAT-1 ( +) sh-MIAT-2 ( +) TNF-α (−) |
Liu et al. (2021) [200] | lncRNA Mancr | Tendon | Mice | Trauma | Increase | ALP OSX RUNX2 | sh-Mancr (−) |
hBMSCs | In vitro | THR Trauma | |||||
Hatzikotoulas et al. (preprint) [42] | lncRNA CASC20 | Blood /saliva Bone HMAD hMSCs | Humans In vitro | THR | Increase | OCN OSX RUNX2 | NA |