Fig. 5

KW-2449 and VPA rescue neurogenesis defects in MECP2-KO organoids. A, B Representative images (A) and quantitation (B) of immunofluorescence staining for KI67 at day 60 in PX330 and MECP2-KO organoids treated with DMSO (control), 1 µM KW2449 or 10 µM VPA for 49 days. n = 3 independent experiments. C–E Representative images (C) and quantitation (D, E) of immunofluorescence staining for TBR1 and CTIP2 at day 60 in PX330 and MECP2-KO organoids treated with DMSO (control), 1 µM KW2449 or 10 µM VPA for 49 days. n = 3 independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001. Data are shown as mean ± SEM; Two-tailed Student’s t-test