Fig. 2

Analysis of hematuria, vascular lesions and micturition. A 3D and 2D representations of hematuria accumulation as a function of post-irradiation time and radiation dose. The white arrow indicates the dose threshold of hematuria onset within 100 days (for each group n = 5). B Cystoscopic studies of vascular lesions at 6 and 12 months post-irradiation. On the left are shown the rats 6 months post-irradiation and on the right the rats 12 months post-irradiation. The photographs shown on the left and in the center of each section are photographs taken during cystoscopy to visualize the vascular lesions. As they represent a three-dimensional image of the lesions, it is not possible to put scale bars. The images on the right represent the bladder once removed and observed with a binocular loupe, the scale bar represents 1 mm. Black arrows indicate vascular lesions, and the dotted lines indicate the outline of the vascular lesions C Detail of vascular lesions according to the groups at 6 months post-irradiation (for each group and time n = 3). D Detail of vascular lesions according to the groups at 12 months post-irradiation (n = 3). E Analysis of micturition at 6 months (n = 8). A statistical test (ANOVA) was performed, p < 0.001 (***), p < 0.0001 (****)