Table 2 Characteristics of rat trials
References | Location | Animal sex | Animal species | Animal weight | Animal year | Group | Type and source of NSPC | Way of administrated | Â | Dose of NSPC | Immunosuppression | Assessment time | Parameter |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Park [37] | Korea | Male | SD rat | 220–230 g | NA | AF64A (n = 15) AF64A + NSC (n = 15) AF64A + ChAT NSC (n = 15) | Human NSC from 15-week fetal brain | ICV | Right ventricle | 1 × 106 | N | 4–5 weeks 8–9 weeks | MWM |
Moghadam [38] | Iran | Male | SD rat | about 300 g | NA | nbM lesion + vehicle (n = 6) nbM lesion + NPC (n = 6) | Mice NPC differentiation from ESC | Stereotactically transplanted | Right nbM | 2 × 105 | Y | 4 weeks | MWM |
Tang [39] | China | Male | Wistar rat | 200–250 g | 3–4 months | Aβ (n = 10) Aβ + NPC (n = 10) | Mice NPC from embryonic fibroblasts | Stereotactically transplanted | Hippocampus | NA | Y | 4 weeks 16 weeks | MWM |
Wu [40] | Japan | Male | Wistar rat | 270–290 g | NA | OA (n = 12) OA + NSC (n = 12) OA + NSC-hNGF-eGFP (n = 12) | Rat NSC from 17-day rat forebrain cerebral cortex | Stereotactically transplanted | Hippocampus and cerebral cortex | 2 × 105 | N | 30 days | MWM |
Chen [41] | China | Male | SD rat | 200–250 g | NA | IgG-saporin (n = 8) IgG-saporin + NSC (n = 8) IgG-saporin + NSC + NGF-PE-PLGA-NPs (N = 8) | Rat NSC from embryonic day 13.5–15.5 | Stereotactically transplanted | Hippocampus and basal forebrain | NA | N | 4 weeks | MWM |
Cui [42] | China | Female | SD rats | NA | NA | Aβ (n = 15) Aβ + NSC (n = 15) Aβ + NSC + DSP (n = 15) | Rat NSC from hippocampus on postnatal day1 | Stereotactically transplanted | Hippocampus | 5 × 105 | N | 4 weeks | MWM |
Hu [43] | China | Female | SD rats | NA | 8 weeks | Aβ (n = 18) Aβ + NSC (n = 18) Aβ + NSC + ASI (n = 18) | Rat NSC from embryonic day 14 | Stereotactically transplanted | Hippocampus | 1 × 105 | N | 4 weeks | MWM |
Shaymaa [44] | Egypt | Male | SD rats | 200–250 g | 3 months | IBO acid (n = 10) IBO acid + NSC (n = 10) IBO acid + NSC  + ROO (n = 10) | Human adult OBNSCs | Stereotactically transplanted | Hippocampus | 2.4 × 105 | Y | 7 weeks | MWM |