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Fig. 9 | Stem Cell Research & Therapy

Fig. 9

From: Synergistic therapeutic effects of intracerebral transplantation of human modified bone marrow-derived stromal cells (SB623) and voluntary exercise with running wheel in a rat model of ischemic stroke

Fig. 9

mRNA expression of BDNF and VEGF in the IBZ. ANOVA detected significant treatment effects on mRNA expressions of BDNF and VEGF, which were significantly up-regulated in the SB623 + Ex group compared to the vehicle, Ex, and SB623 groups, respectively (each group: n = 6, BDNF: F(3, 20) = 10.1, p < 0.001, VEGF: F(3, 20) = 13.1, p < 0.001) (mean ± SE, BDNF: F(3, 20) = 10.1, p < 0.001, VEGF: F(3, 20) = 13.1, p < 0.001). The Ex group and the SB623 group significantly up-regulated mRNA expressions of BDNF and VEGF compared to the vehicle group (*p < 0.05, **p < 0.01 vs. vehicle group, #p < 0.05 vs. SB623 + Ex group). Abbreviation: BDNF: brain-derived neurotrophic factor, VEGF: vascular endothelial growth factor, IBZ: ischemic boundary zone

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