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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Adipose-derived stem cell spheroid-laden microbial transglutaminase cross-linked gelatin hydrogel for treating diabetic periodontal wounds and craniofacial defects

Fig. 5

Osteogenic differentiation of ADSCs after 10 days pretreatment in vitro and the micro-CT assessments of diabetic osseous defect healing at day 28. A Mineralized matrix deposition by Alizarin Red. Scale bar: 50 µm. B The concentration of Alizarin Red. C Representative slices from the images. Scale bar: 1 mm D Percentage bone volume (BV/TV) Tb.N. F Tb.Th. Dashed lines indicate the borders of osseous defects. (In (B), significant difference compared to the unpretreated ADSCs: **p < 0.01; in (D-F), among groups with diabetes, significant difference compared to DB-CL: *p < 0.05, **p < 0.01, ***p < 0.001)

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