Table 3 Clinical trials of MSC-EVs in periodontitis and other diseases
Disease | MSC type | Country | NCT number | Status |
|---|---|---|---|---|
Oral diseases | ||||
 Periodontitis | ADSCs | Egypt | NCT04270006 | Unknown |
Trauma | ||||
 Burn wounds | BMSCs | Not shown | NCT05078385 | Not yet recruiting |
 Wound healing | ADSCs | China | NCT05475418 | Not yet recruiting |
Gastrointestinal diseases | ||||
 Medically refractory Crohn's disease | Adult allogeneic BMSCs | Not shown | NCT05130983 | Not yet recruiting |
 Medically refractory ulcerative colitis | Adult allogeneic BMSCs | Not shown | NCT05176366 | Not yet recruiting |
 Resistant perianal fistula | Placental mesenchymal stem cell | Iran | NCT05499156 | Not yet recruiting |
 Complex anal fistula | Placental mesenchymal stem Cell | Iran | NCT05402748 | Recruiting |
Neonatal-related diseases | ||||
 Preterm neonates at high risk of bonchopulmonary dysplasia | BMSCs | US | NCT03857841 | Terminated |
 Extremely low birth weight infants | MSCs | Russian | NCT05490173 | Not yet recruiting |
Organ transplant | ||||
 Abdominal solid organ transplant | BMSCs | Not shown | NCT05215288 | Not yet recruiting |
Autoimmune disease | ||||
 Dystrophic epidermolysis bullosa wounds | BMSCs | Not shown | NCT04173650 | Not yet recruiting |
COVID-19 | ||||
 Mild-to-moderate COVID-19 | BMSCs | US | NCT05125562 | Not yet recruiting |
 COVID-19 Moderate-to-Severe ARDS | BMSCs | US | NCT05354141 | Recruiting |
 Post-acute COVID-19 and chronic post-COVID-19 syndrome | BMSCs | Not shown | NCT05116761 | Not yet recruiting |
 COVID-19-associated ARDS | BMSCs | US | NCT04493242 | Completed |