Skip to main content
Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Dose-specific efficacy of adipose-derived mesenchymal stem cells in septic mice

Fig. 3

Effect of ADSCs treatment on CLP-induced bacterial burden and systemic inflammation. Blood samples were collected from CLP mice that received vehicle or different doses of ADSCs treatment at 6 h post-treatment. Whole blood samples were plated on Columbia blood agar plates with a 100-fold dilution in sterile saline and incubated overnight at 37 °C. Bacterial numbers were analyzed by colony forming units (CFU) (A). The plasma levels of endotoxin were measured by ELISA (B). Changes in systemic inflammation in CLP mice after ADSCs treatment were assessed by examining the plasma levels of 23 cytokines using a multiple cytokine assay. Plasma samples from sham-operated mice were used as reference controls. The expression patterns of cytokines were visualized by heatmap (C). n = 5 in each group. *, p < 0.05, significantly different from the CLP + Vehicle group

Back to article page