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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Flow-dependent shear stress affects the biological properties of pericyte-like cells isolated from human dental pulp

Fig. 7

Effects of inflammatory microenvironment on hDPSCs exposed to FSS. A Heatmap of RPPA analysis carried out on phosphorylated proteins in hDPSCs, after co-culture with PBMCs in static and dynamic conditions. Histograms showing the most prominent signaling pathways. Data are represented as mean ± SD, and statistical analysis was carried out by unpaired Student’s t test; ***P < 0.001, **P < 0.01 vs hDPSCs in static condition (n = 5). B FACS analysis of CD45 on PBMCs following static and dynamic co-culture with hDPSCs. C Real-time PCR analysis of different cytokines was performed on PBMCs after hDPSCs co-culture in static and dynamic conditions. Histograms represent the mean ± SD mRNA fold-change (n = 5). Statistical analysis was carried out by one-way ANOVA followed by Newman–Keuls post hoc test. ***P < 0.001, *P < 0.05 vs. PBMCs alone in static condition; °°°P < 0.001, °P < 0.05 vs PBMCs after DPSCs co-culture in static conditions

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