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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Single cell and lineage tracing studies reveal the impact of CD34+ cells on myocardial fibrosis during heart failure

Fig. 7

Cell composition of human heart. A UMAP plot displaying the major cell types and color-coded cell clusters of human heart, n = 22,537 cells. (Control: normal heart; HF: Heart Failure). B Bar chart showing the percentage of major cell types among human heart (Control: normal heart; HF: Heart Failure). C Pie plot showing the percentage of major cell types among human heart between control and heart failure. D UMAP plot displaying distribution of fibroblast subpopulations between control and heart failure group, n = 10,242 cells, resolution = 0.5. E Bar chart showing the percentage of subclusters in datasets between control and diseased heart (HF). F Violin plot showing the expression of selected representative cell marker genes in each cell cluster. G Dot plot showing the expression of selected fibroblast cell marker genes in each cell cluster. Dot size reflects the percentage of cells expressing the selected gene in each cell cluster. H Bar plot showing the GO datasets score among fibroblast subclusters. I Volcano plot showing the DEGs between control and heart failure (p-value < 0.01 and log2FC > 1 was labeled)

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