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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: Single cell and lineage tracing studies reveal the impact of CD34+ cells on myocardial fibrosis during heart failure

Fig. 8

Characterization of CD34 + cells in human hearts. A UMAP plot displaying the major cell types and color-coded CD34 + cells of human heart with the disease, n = 9,457 cells. B Heatmap showing the expression of top five differentially expressed genes in each cell subcluster. C UMAP plot displaying distribution of fibroblast subpopulations between control and diseased heart, n = 4,860 cells, resolution = 0.5. D Bar chart showing the percentage of subclusters in datasets between control and diseased heart. E Dot plot showing expression levels of top five differentially expressed genes in each cell cluster. Dot size reflects the percentage of cells expressing the selected gene in each cell cluster. F Bar plot showing the GO datasets score among fibroblast subclusters. G. Representative immunostaining images showing staining of CD34 and vimentin, PDGFRA and POSTN in human heart (scale bar = 20 μm and 100 μm). H Sirius red and Masson staining showing different degrees of fibrosis between normal heart (control) and heart with heart failure (HF)

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Stem Cell Research & Therapy

ISSN: 1757-6512