Fig. 1From: ETV2/ER71, the key factor leading the paths to vascular regeneration and angiogenic reprogrammingSchematic diagram of ETV2 function. ETV2 has multiple functions in the regulation of the cardiovascular system. The development of hematopoietic and endothelial cells is critically dependent on ETV2 as evidenced by a complete lack of both lineages in Etv2 deficient embryos. In adults, endothelial ETV2 is required for new vessel formation in response to injury. Furthermore, ECs lacking Etv2 have impaired ability to support tumor growth. In bone marrow (BM), ETV2 regulates hematopoietic stem cell proliferation, contributing to BM hematopoiesis. Recent studies have shown that ETV2 can directly generate ECs from non-ECs and PSCs. Created in BioRender.comBack to article page