From: ETV2/ER71, the key factor leading the paths to vascular regeneration and angiogenic reprogramming
Cell source | Delivery method | Factors | In vivo functional assay | Outcome | References |
---|---|---|---|---|---|
Human amniotic cells | Lentivirus | ETV2, FLI1, ERG1 and inhibition of TGFβ | Angiogenesis | Improved perfusion vessels | Ref. [49] |
Mouse adult skin fibroblasts | Lentivirus | Foxo1, Etv2, Klf2, Tal1 and Lmo2 | Hindlimb ischemia | Improved blood flow recovery | Ref. [50] |
Human adult skin fibroblasts | Lentivirus | ETV2 | Hindlimb ischemia | Improved perfusion vessels | Ref. [9] |
Human dermal fibroblasts | Lentivirus | ETV2 | Hindlimb ischemia | Direct vascular incorporation and angiogenesis | Ref. [10] |
Human adipose-derived stem cells | Lentivirus | ETV2 and inhibition of TGFβ | Hindlimb ischemia | Promoted revascularization | Ref. [51] |
Vascular adventitial Sca1 + progenitor cells | Adenovirus | ETV2 | Femoral artery wire injury model | Improved vascular remodeling | Ref. [52] |
Zebrafish fast muscle cells | Transgenic and Heat Shock | ETV2 | Observational study (time lapse imaging/microangiography) | Integration of ECs into vascular network and subsequent blood circulation | Ref. [53] |
Human dermal fibroblasts | Lentivirus | ETV2 and hypoxia conditions (5% oxygen) | Not conducted | Improved reprogramming efficacy vs normoxia | Ref. [55] |