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Table 1 Summary of ETV2-mediated direct reprogramming to endothelial cells

From: ETV2/ER71, the key factor leading the paths to vascular regeneration and angiogenic reprogramming

Cell source

Delivery method

Factors

In vivo functional assay

Outcome

References

Human amniotic cells

Lentivirus

ETV2, FLI1, ERG1 and inhibition of TGFβ

Angiogenesis

Improved perfusion vessels

Ref. [49]

Mouse adult skin fibroblasts

Lentivirus

Foxo1, Etv2, Klf2, Tal1 and Lmo2

Hindlimb ischemia

Improved blood flow recovery

Ref. [50]

Human adult skin fibroblasts

Lentivirus

ETV2

Hindlimb ischemia

Improved perfusion vessels

Ref. [9]

Human dermal fibroblasts

Lentivirus

ETV2

Hindlimb ischemia

Direct vascular incorporation and angiogenesis

Ref. [10]

Human adipose-derived stem cells

Lentivirus

ETV2 and inhibition of TGFβ

Hindlimb ischemia

Promoted revascularization

Ref. [51]

Vascular adventitial Sca1 + progenitor cells

Adenovirus

ETV2

Femoral artery wire injury model

Improved vascular remodeling

Ref. [52]

Zebrafish fast muscle cells

Transgenic and Heat Shock

ETV2

Observational study (time lapse imaging/microangiography)

Integration of ECs into vascular network and subsequent blood circulation

Ref. [53]

Human dermal fibroblasts

Lentivirus

ETV2 and hypoxia conditions (5% oxygen)

Not conducted

Improved reprogramming efficacy vs normoxia

Ref. [55]