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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: MiR-21-5p regulates the dynamic of mitochondria network and rejuvenates the senile phenotype of bone marrow stromal cells (BMSCs) isolated from osteoporotic SAM/P6 mice

Fig. 6

MiR-21 improves regenerative potential of BMSCs in senile osteoporotic SAM/P6 mice strain in vivo. During the procedure, two mice (n = 2) were operated. A The photograph of critical-size cranial defects during the mice operation. B The RTG images of SAM/P6 mice 2 weeks after the procedure. The defects were marked on the images using red circles. Scale bar is equal to 5 mm. C The external and internal photographs obtained during µCT analyses of the defects in SAM/P6 mice. The ratio of newly formed tissue to the initial defect area was presented as a bar graph (E) and the new bone was indicated with red arrows. D The SEM–EDX analyses of the defects, as well as calcium and phosphorus distribution in SAM/P6 mice. The images were captured under 35-fold magnification and the scale bar is equal to 200 µm. The SEM–EDX signal of calcium and phosphorus concentration were measured and presented as bar graphs (F, G). The mRNA level of H miR-21-5p, I miR-124-3p, J Runx-2 and K Trap within the defect site. Significant differences between groups are indicated with asterisk: *p < 0.05, **p < 0.01, ***p < 0.001. Non-significant differences are marked as ns

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